2-Amino-4,6-dichloropyridine

Base Information

• Chemical Name: 2-Amino-4,6-dichloropyridine
• CAS No.: 116632-24-7
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.006
• Hs Code.: 2933399090
• European Community (EC) Number: 640-776-3
• DSSTox Substance ID: DTXSID50415706
• Nikkaji Number: J3.493.368E
• Wikidata: Q72435777
• Mol file: 116632-24-7.mol

Synonyms:2-Amino-4,6-dichloropyridine;116632-24-7;4,6-dichloropyridin-2-amine;4,6-dichloro-pyridin-2-ylamine;MFCD04037218;2-AMINO-4,6-DICHLORO-PYRIDINE;2-Pyridinamine, 4,6-dichloro-;4,6-dichloro-2-pyridinamine;SCHEMBL247619;4,6-Dichloropyridine-2-amine;4,6-dichloropyridin-2-ylamine;DTXSID50415706;AGJMDETXSYICGZ-UHFFFAOYSA-N;AM699;4,6-bis(chloranyl)pyridin-2-amine;AKOS006276744;2-Amino-4 pound not6-dichloropyridine;AB17004;AC-7492;CS-W003134;PS-5587;SY010500;2-amino-4,6-dichloropyridine, AldrichCPR;FT-0630125;J3.493.368E;EN300-106735;A803653;W-204907

Chemical Property of 2-Amino-4,6-dichloropyridine

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.00242mmHg at 25°C
• Melting Point: 112.5 °C
• Refractive Index: 1.622
• Boiling Point: 287.9 °C at 760 mmHg
• PKA: 1.76±0.35(Predicted)
• Flash Point: 127.9 °C
• PSA: 38.91000
• Density: 1.497 g/cm³
• LogP: 2.55180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 161.9751535
• Heavy Atom Count: 9
• Complexity: 99

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4,6-Dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1N)Cl)Cl
• Uses: 2-Amino-4,6-Dichloropyridine is a useful research chemical.

Technology Process of 2-Amino-4,6-dichloropyridine

There total 4 articles about 2-Amino-4,6-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (4,6-dichloropyridin-2-yl)carbamate (1017789-38-6) → 2-amino-4,6-dichloropyridine (116632-24-7)

Guidance literature:

In acetonitrile; at 300 ℃; under 75007.5 Torr;

DOI:10.1021/acs.orglett.6b00378

Reference yield: 67.0%

2,4,6-trichloropyridine (16063-69-7) → 2,6-dichloro-[4]pyridylamine (2587-02-2) + 2-amino-4,6-dichloropyridine (116632-24-7)

Guidance literature:

With ammonium hydroxide; In water; at 130 ℃; for 4h;

DOI:10.1021/jm8005959

Reference yield:

4,6-dichloro-pyridine-2-carbonyl azide → 2-amino-4,6-dichloropyridine (116632-24-7)

Guidance literature:

With acetic acid;

upstream raw materials:

2,4,6-trichloropyridine

tert-butyl (4,6-dichloropyridin-2-yl)carbamate

Downstream raw materials:

6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

4-chloro-6-(2-phenylethynyl)pyridin-2-amine

C₂₃H₃₁N₅O₂

1-[4-chloro-3-(ethylamino)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-[1(1R)-1-phenylethyl]urea

Refernces

• 1、 Altenbach, Robert J.,Adair, Ronald M.,Bettencourt, Brian M.,Black, Lawrence A.,Fix-Stenzel, Shannon R.,Gopalakrishnan, Sujatha M.,Hsieh, Gin C.,Liu, Huaqing,Marsh, Kennan C.,McPherson, Michael J.,Milicic, Ivan,Miller, Thomas R.,Vortherms, Timothy A.,Warrior, Usha,Wetter, Jill M.,Wishart, Neil,Witte, David G.,Honore, Prisca,Esbenshade, Timothy A.,Hancock, Arthur A.,Brioni, Jorge D.,Cowart, Marlon D.. "Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands". supporting information; experimental part. p. 6571 - 6580. Retrieved 2009/11/30.