2-BOC-AMINO-4,6-DICHLOROPYRIDINE

Base Information

• Chemical Name: 2-BOC-AMINO-4,6-DICHLOROPYRIDINE
• CAS No.: 1017789-38-6
• Molecular Formula: C₁₀H₁₂Cl₂N₂O₂
• Molecular Weight: 263.123
• Hs Code.: 2933399090
• Mol file: 1017789-38-6.mol

Synonyms:2-BOC-AMINO-4,6-DICHLOROPYRIDINE;(4,6-DICHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property of 2-BOC-AMINO-4,6-DICHLOROPYRIDINE

Chemical Property:

• PSA: 51.22000
• LogP: 3.80840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Boc-amino-4,6-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BOC-AMINO-4,6-DICHLOROPYRIDINE

There total 1 articles about 2-BOC-AMINO-4,6-DICHLOROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-4,6-dichloropyridine (116632-24-7) → tert-butyl (4,6-dichloropyridin-2-yl)carbamate (1017789-38-6)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 12h;

Reference yield: 95.0%

tert-butyl (4,6-dichloropyridin-2-yl)carbamate (1017789-38-6) → 2-amino-4,6-dichloropyridine (116632-24-7)

Guidance literature:

In acetonitrile; at 300 ℃; under 75007.5 Torr;

DOI:10.1021/acs.orglett.6b00378

Reference yield:

tert-butyl (4,6-dichloropyridin-2-yl)carbamate (1017789-38-6) → (R)-1-(4,6-dichloro-5-cyanopyridin-2-yl)-3-(1-phenylethyl)urea (1589541-57-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

1.2: 0.5 h

2.1: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: trichloroacetonitrile / 2 h / 85 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1H-imidazole / chloroform / 12 h / 0 - 20 °C

5.2: 2 h / 20 °C

With 1H-imidazole; n-butyllithium; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; trichloroacetonitrile; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform;

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-4,6-dichloropyridine

Downstream raw materials:

6-amino-2,4-dichloronicotinonitrile

(R)-1-(4,6-dichloro-5-cyanopyridin-2-yl)-3-(1-phenylethyl)urea

(R)-1-(3-amino-4-chloro-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea

(R)-1-(3-amino-4-methoxy-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea

Refernces