4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one

Base Information

Chemical Name:4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one
CAS No.:1198752-78-1
Molecular Formula:C₂₉H₂₈Cl₂O₂S
Molecular Weight:511.512
Hs Code.:

Synonyms:4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one

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Chemical Property of 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one

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Technology Process of 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one

There total 8 articles about 4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1198752-76-9
5-chloro-4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-6H-pyran-3-one

: 930-69-8
sodium thiophenolate

: 1198752-78-1
4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one

Guidance literature:: In dimethyl sulfoxide; at 150 ℃; for 24h;

Reference yield:

: 14922-91-9
2-ethyl-5-bromoaniline

: 1198752-78-1
4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / water / Reflux

1.2: 5 °C / Cooling with ice/salt bath

1.3: 20 - 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / -78 - 20 °C

2.2: -78 - 20 °C

3.1: mercury(II) diacetate / chloroform / 5 h / 40 °C / Inert atmosphere

4.1: dmap / chloroform; toluene / 2 h / 80 °C

5.1: cesium fluoride / 1,4-dioxane / 0.75 h / Inert atmosphere

5.2: 3 h / 100 °C / Inert atmosphere

6.1: thionyl chloride / N,N-dimethyl-formamide / 0 - 20 °C

7.1: dimethyl sulfoxide / 24 h / 150 °C

With dmap; thionyl chloride; sulfuric acid; isopropylmagnesium chloride; cesium fluoride; mercury(II) diacetate; In tetrahydrofuran; 1,4-dioxane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1033760-94-9
4-bromo-1-ethyl-2-iodobenzene

: 1198752-78-1
4-(2',4'-dichloro-4-ethylbiphen-3-yl)-2,2,6,6-tetramethyl-5-phenylsulfanyl-6H-pyran-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / -78 - 20 °C

1.2: -78 - 20 °C

2.1: mercury(II) diacetate / chloroform / 5 h / 40 °C / Inert atmosphere

3.1: dmap / chloroform; toluene / 2 h / 80 °C

4.1: cesium fluoride / 1,4-dioxane / 0.75 h / Inert atmosphere

4.2: 3 h / 100 °C / Inert atmosphere

5.1: thionyl chloride / N,N-dimethyl-formamide / 0 - 20 °C

6.1: dimethyl sulfoxide / 24 h / 150 °C

With dmap; thionyl chloride; isopropylmagnesium chloride; cesium fluoride; mercury(II) diacetate; In tetrahydrofuran; 1,4-dioxane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;