N₁-(3-fluorophenyl)-N₂-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine

Base Information

• Chemical Name: N₁-(3-fluorophenyl)-N₂-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine
• CAS No.: 1303559-32-1
• Molecular Formula: C₁₈H₂₃FN₄
• Molecular Weight: 314.406

Synonyms:N₁-(3-fluorophenyl)-N₂-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine

Chemical Property of N₁-(3-fluorophenyl)-N₂-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine

Chemical Property:

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Technology Process of N₁-(3-fluorophenyl)-N₂-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine

There total 3 articles about N₁-(3-fluorophenyl)-N₂-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

2-(3-fluorophenylamino)-N-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)acetamide (1227094-23-6) → N1-(3-fluorophenyl)-N2-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine (1303559-32-1)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanamine hydrochloride (1227095-56-8) → N1-(3-fluorophenyl)-N2-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine (1303559-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; PyBOP / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With borane-THF; PyBOP; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

2-(3-fluorophenylamino)acetic acid (5319-43-7) → N1-(3-fluorophenyl)-N2-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)ethane-1,2-diamine (1303559-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; PyBOP / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With borane-THF; PyBOP; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2-(3-fluorophenylamino)acetic acid

2-(3-fluorophenylamino)-N-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)acetamide

2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanamine hydrochloride

Downstream raw materials:

N-(2-(3-fluorophenylamino)ethyl)-N-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)-1H-imidazole-1-carboxamide

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