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2-[(3-fluorophenyl)amino]acetic acid is a chemical compound with the molecular formula C8H8FNO2. It is an aromatic amino acid derivative, featuring a 3-fluorophenyl group attached to the amino group, and a carboxylic acid group at the 2-position of the acetic acid backbone. 2-[(3-fluorophenyl)amino]acetic acid is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as a building block for the development of new drugs. Its unique structure, with the fluorine atom providing distinct electronic and steric properties, can influence the compound's reactivity and biological activity. The compound is typically synthesized through various chemical reactions and can be used as an intermediate in the preparation of more complex molecules.

5319-43-7

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5319-43-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5319-43-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,1 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5319-43:
(6*5)+(5*3)+(4*1)+(3*9)+(2*4)+(1*3)=87
87 % 10 = 7
So 5319-43-7 is a valid CAS Registry Number.

5319-43-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3-fluorophenylamino)acetic acid

1.2 Other means of identification

Product number -
Other names 3-fluorophenylglycine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5319-43-7 SDS

5319-43-7Relevant academic research and scientific papers

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

Wang, Kun,Wu, Jia-Jing,Xin–Zhang,Zeng, Qing-Xuan,Zhang, Na,Huang, Wei-Jin,Tang, Sheng,Wang, Yan-Xiang,Kong, Wei-Jia,Wang, You-Chun,Li, Ying-Hong,Song, Dan-Qing

, (2021/08/03)

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potential effects against both pseudotyped and authentic SARS-CoV-2, as well as SARS-CoV and MERS-CoV, indicating a broad-spectrum anti-coronavirus profile. The mechanism study disclosed that 8a might block a late stage of viral entry, mainly via inhibiting host cathepsin B activity rather than directly targeting cathepsin B protein. Also, 8a could significantly reduce the release of multiple inflammatory cytokines in a time- and dose-dependent manner, such as IL-6, IL-1β, IL-8 and MCP-1, the major contributors to cytokine storm. Therefore, 8a is a promising agent with the advantages of broad-spectrum anti-coronavirus and anti-cytokine effects, thus worthy of further investigation.

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