(S)-1-phenyl-2-benzylaminoethylamine

Base Information

• Chemical Name: (S)-1-phenyl-2-benzylaminoethylamine
• CAS No.: 155220-76-1
• Molecular Formula: C₁₅H₁₈N₂
• Molecular Weight: 226.321
• Mol file: 155220-76-1.mol

Synonyms:(S)-1-phenyl-2-benzylaminoethylamine

Chemical Property of (S)-1-phenyl-2-benzylaminoethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-phenyl-2-benzylaminoethylamine

There total 7 articles about (S)-1-phenyl-2-benzylaminoethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-2-benzyl-4-phenyl-1,2,5-thiadiazolidine 1,1-dioxide → (S)-1-phenyl-2-benzylaminoethylamine (155220-76-1)

Guidance literature:

With hydrazine hydrate; at 110 ℃; for 14h;

DOI:10.1021/acs.joc.0c02279

Reference yield: 80.0%

(S)-2-amino-N-benzyl-2-phenylacetamide (155322-81-9) → (S)-1-phenyl-2-benzylaminoethylamine (155220-76-1)

Guidance literature:

With borane; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)73744-0

Reference yield:

(S)-2-phenylglycine (2935-35-5) → (S)-1-phenyl-2-benzylaminoethylamine (155220-76-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / aq. NaOH

2: N-methylmorpholine

4: 100 percent / H₂ / Pd-C / methanol

5: 80 percent / BH₃ / tetrahydrofuran

With 4-methyl-morpholine; sodium hydroxide; borane; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4039(00)73744-0

upstream raw materials:

(S)-2-amino-N-benzyl-2-phenylacetamide

(S)-2-phenylglycine

(S)-N-(benzyloxycarbonyl)phenylglycine

Downstream raw materials:

(3R,5S,8aS)-1-Benzyl-5-methyl-3-phenyl-octahydro-imidazo[1,2-a]pyridine

(3S,5R,8aR)-1-Benzyl-5-methyl-3-phenyl-octahydro-imidazo[1,2-a]pyridine

(3S,5R,8aR)-1-Benzyl-5-ethyl-3-phenyl-octahydro-imidazo[1,2-a]pyridine

(3S,5S,7R,7aS)-1-benzyl-5,7-bis(tert-butoxycarbonyl)-3-phenylhexahydropyrrolo[1,2-a]imidazole