(3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole

Base Information

• Chemical Name: (3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole
• CAS No.: 175792-77-5
• Molecular Formula: C₂₆H₃₂N₂O₄
• Molecular Weight: 436.551

Synonyms:(3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole

Chemical Property of (3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole

There total 2 articles about (3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

bromoacetic acid tert-butyl ester (5292-43-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + (S)-1-benzyl-4-phenyl-4,5-dihydroimidazole (175792-71-9) → (3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole (175792-77-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/0040-4039(96)00113-X

Reference yield:

(S)-1-phenyl-2-benzylaminoethylamine (155220-76-1) → (3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole (175792-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH / Heating

2: 65 percent / DBU / tetrahydrofuran / 6 h / Heating

With toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)00113-X

Reference yield: 17.0%

(3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole (175792-77-5) → (2S,4R)-1-[(S)-2-benzylamino-1-phenylethyl]-2-tertbutoxycarbonyl-4-methoxycarbonylpyrrolidine + (2S,4S)-1-[(S)-2-benzylamino-1-phenylethyl]-2-tertbutoxycarbonyl-4-methoxycarbonylpyrrolidine

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)00114-1

upstream raw materials:

bromoacetic acid tert-butyl ester

acrylic acid methyl ester

(S)-1-benzyl-4-phenyl-4,5-dihydroimidazole

(S)-1-phenyl-2-benzylaminoethylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 175792-77-5 (3S,5S,7R,7aS)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-3-phenylhexahydropyrrolo[1,2-a]imidazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send