(2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol

Base Information

Chemical Name:(2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol
CAS No.:1270018-29-5
Molecular Formula:C₂₁H₂₀ClN₅O₅S
Molecular Weight:489.939
Hs Code.:

Synonyms:(2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol

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Chemical Property of (2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol

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Technology Process of (2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol

There total 7 articles about (2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 288-94-8
1H-tetrazole

: 1270018-18-2
((2R,3S,4R,5R,6S)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

: 1270018-29-5
(2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 72h; Inert atmosphere;

Reference yield:

: 288-94-8
1H-tetrazole

: C₂₇H₂₆ClNO₇S₂

: 1270018-31-9
(2R,3S,4R,5R,6S)-2-((1H-tetrazol-1-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol

: 1270018-29-5
(2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 72h;
DOI:10.1016/j.bmcl.2010.11.115

Reference yield:

: 1225430-40-9
2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)acetic acid

: 1270018-31-9
(2R,3S,4R,5R,6S)-2-((1H-tetrazol-1-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol

: 1270018-29-5
(2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: Lawessons reagent / tetrahydrofuran / 85 °C

3: boron trichloride / dichloromethane / 0 °C

4: 2,6-dimethylpyridine / 15 h / 20 °C

5: triethylamine / N,N-dimethyl-formamide / 72 h / 80 °C

With Lawessons reagent; 4-methyl-morpholine; 2,6-dimethylpyridine; boron trichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.11.115