2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine

Base Information

• Chemical Name: 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine
• CAS No.: 131947-30-3
• Molecular Formula: C₂₀H₁₆N₂S
• Molecular Weight: 316.426
• Mol file: 131947-30-3.mol

Synonyms:2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine

Chemical Property of 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine

Chemical Property:

Purity/Quality:

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Technology Process of 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine

There total 33 articles about 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di(p-tolyl) disulfide (103-19-5) + 2-phenylimidazo[1,2-a]pyridine (4105-21-9) → 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine (131947-30-3)

Guidance literature:

With 5-ethyl-10-(2-hydroxylethyl)-7,8-dimethylisoalloxazinium triflate; iodine; oxygen; In acetonitrile; at 50 ℃; for 4h; under 760.051 Torr; Green chemistry;

DOI:10.1021/acs.joc.8b01878

Reference yield: 99.0%

sodium 4-methylbenzenesulfinate (824-79-3) + 2-phenylimidazo[1,2-a]pyridine (4105-21-9) → 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine (131947-30-3)

Guidance literature:

With iodine; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1039/c4ra17237j

Reference yield: 95.0%

p-toluenesulfonyl chloride (98-59-9) + 2-phenylimidazo[1,2-a]pyridine (4105-21-9) → 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine (131947-30-3)

Guidance literature:

With copper(l) iodide; triphenylphosphine; In toluene; at 130 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Catalytic behavior;

DOI:10.1039/c5ob02475g

upstream raw materials:

para-thiocresol

2-phenyl-3-chloroimidazo<1,2-a>pyridine

2-aminopyridine

2-hydroxy-2-(2-pyridylamino)-1,1,1-trichloroethane