4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

Base Information

Chemical Name:4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide
CAS No.:1093262-89-5
Molecular Formula:C₂₀H₁₅Cl₃FN₃O₃
Molecular Weight:470.715
Hs Code.:

Synonyms:4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

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Chemical Property of 4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

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Technology Process of 4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

There total 14 articles about 4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1093256-24-6
N-({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)-4-chloro-2-ethyl-1H-imidazole-5-carboxamide

: 1093262-89-5
4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

Guidance literature:: With sodium periodate; osmium(VIII) oxide; tert-butyl alcohol; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

: 145824-12-0
4-chloro-2-ethyl-1H-imidazole-5-carboxaldehyde

: 1093262-89-5
4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 6 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: sodium periodate; osmium(VIII) oxide; tert-butyl alcohol / tetrahydrofuran; water / 4 h / 20 °C

With sodium chlorite; sodium periodate; osmium(VIII) oxide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; N-ethyl-N,N-diisopropylamine; HATU; tert-butyl alcohol; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 146650-65-9
2-ethyl-4-chloro-5-(hydroxymethyl)-imidazole

: 1093262-89-5
4-chloro-N-({4-chloro-3-[(3-chloro-5-formylphenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / 1,4-dioxane; dichloromethane / 6.5 h / Reflux

2: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 6 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: sodium periodate; osmium(VIII) oxide; tert-butyl alcohol / tetrahydrofuran; water / 4 h / 20 °C

With manganese(IV) oxide; sodium chlorite; sodium periodate; osmium(VIII) oxide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; N-ethyl-N,N-diisopropylamine; HATU; tert-butyl alcohol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;