(5-Chloro-2-ethyl-1h-imidazol-4-yl)methanol

Base Information

• Chemical Name: (5-Chloro-2-ethyl-1h-imidazol-4-yl)methanol
• CAS No.: 146650-65-9
• Molecular Formula: C₆H₉ClN₂O
• Molecular Weight: 160.603
• DSSTox Substance ID: DTXSID30437123
• Wikidata: Q82252501
• Mol file: 146650-65-9.mol

Synonyms:146650-65-9;(5-chloro-2-ethyl-1h-imidazol-4-yl)methanol;(5-CHLORO-2-ETHYL-1H-IMIDAZOL-4-YL)-METHANOL;(4-chloro-2-ethyl-1H-imidazol-5-yl)methanol;SCHEMBL3027998;DTXSID30437123;FFASZXPEKIZOQX-UHFFFAOYSA-N;AKOS006294862;AB27195;FT-0760747;2-ethyl-4-chloro-5-(hydroxymethyl) imidazole;A808533

Chemical Property of (5-Chloro-2-ethyl-1h-imidazol-4-yl)methanol

Chemical Property:

• PSA: 48.91000
• LogP: 1.11780
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 160.0403406
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

97% ^*data from raw suppliers

(5-Chloro-2-ethyl-1H-imidazol-4-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=NC(=C(N1)CO)Cl

Technology Process of (5-Chloro-2-ethyl-1h-imidazol-4-yl)methanol

There total 6 articles about (5-Chloro-2-ethyl-1h-imidazol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chloro-2-ethyl-5-{[(phenylmethyl)oxy]methyl}-1H-imidazole (1093261-76-7) → 2-ethyl-4-chloro-5-(hydroxymethyl)-imidazole (146650-65-9)

Guidance literature:

With methanesulfonic acid; In chloroform; at 20 ℃; for 1h;

DOI:10.1021/jm301294g

Reference yield: 56.0%

2-ethyl-5-hydroxymethyl-1H-imidazole (72993-43-2) → 2-ethyl-4-chloro-5-(hydroxymethyl)-imidazole (146650-65-9)

Guidance literature:

With N-chloro-succinimide; In 1,4-dioxane; 2-methoxy-ethanol; at 20 ℃; for 24h;

DOI:10.1002/ardp.200600013

Reference yield: 43.0%

2-ethyl-4,5-bis(hydroxymethyl)-imidazole (94388-89-3) + carbon dioxide (124-38-9,18923-20-1) → 2-ethyl-4-chloro-5-(hydroxymethyl)-imidazole (146650-65-9)

Guidance literature:

With sodium hypochlorite; In water;

upstream raw materials:

2-ethyl-5-hydroxymethyl-1H-imidazole

1,4-dioxane

2-ethyl-4,5-bis(hydroxymethyl)-imidazole

trichloroisocyanuric acid

Downstream raw materials:

ethyl 1-[[3-bromo-2-(2-aminophenyl)-5-benzofuranyl]methyl]-4-chloro-2-ethyl-1H-imidazole-5-carboxylate

1-[[3-Bromo-2-[2-[[(1,1-dimethylethoxy)carbonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-chloro-2-ethyl-1H-imidazole-5-carboxaldehyde

3-[3-Bromo-2-(2-tert-butoxycarbonylamino-phenyl)-benzofuran-5-ylmethyl]-5-chloro-2-ethyl-3H-imidazole-4-carboxylic acid