N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Base Information

Chemical Name:N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide
CAS No.:226411-05-8
Molecular Formula:C₃₃H₃₆FN₃O
Molecular Weight:509.667
Hs Code.:

Synonyms:N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Chemical Property:

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Technology Process of N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

There total 8 articles about N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 226411-04-7
2-chloro-N-<1-(4-N-methyl-N-benzylamino-2-fluorophenyl)-2-propyl>acetamide

: 103-49-1
dibenzylamine

: 226411-05-8
N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Yield given;
DOI:10.1016/S0223-5234(99)80047-6

Reference yield:

: 372-19-0
meta-fluoroaniline

: 226411-05-8
N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Guidance literature:: Multi-step reaction with 8 steps

1: 72 percent / 2 h / Heating

2: LiAlH₄ / tetrahydrofuran; diethyl ether / 4 h / Heating

3: K₂CO₃, KI / dimethylformamide / 100 °C

4: POCl₃ / 2 h / 100 °C

5: NH₄OAc / ethanol / 5 h / Heating

6: LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / Heating

7: 52 percent / aq. NaOH / toluene / 1 h / 0 °C

8: K₂CO₃, KI / dimethylformamide / 4 h / 100 °C

With sodium hydroxide; lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; potassium iodide; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0223-5234(99)80047-6

Reference yield:

: 1428-10-0
N-(3-fluorophenyl)formamide

: 226411-05-8
N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Guidance literature:: Multi-step reaction with 7 steps

1: LiAlH₄ / tetrahydrofuran; diethyl ether / 4 h / Heating

2: K₂CO₃, KI / dimethylformamide / 100 °C

3: POCl₃ / 2 h / 100 °C

4: NH₄OAc / ethanol / 5 h / Heating

5: LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / Heating

6: 52 percent / aq. NaOH / toluene / 1 h / 0 °C

7: K₂CO₃, KI / dimethylformamide / 4 h / 100 °C

With sodium hydroxide; lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; potassium iodide; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0223-5234(99)80047-6