3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline

Base Information

• Chemical Name: 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline
• CAS No.: 1085709-02-9
• Molecular Formula: C₂₀H₁₆N₆S
• Molecular Weight: 372.453
• Mol file: 1085709-02-9.mol

Synonyms:3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline

Chemical Property of 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline

There total 2 articles about 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-phenyl-3-(4-amino-5-thioxo-1,2,4-triazol-3-yl) β-carboline (1085708-98-0) + methyl iodide (74-88-4) → 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline (1085709-02-9)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2008.10.008

Reference yield:

3-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-1-phenyl-9H-β-carboline (1085708-98-0) + methyl iodide (74-88-4) → 3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline (1085709-02-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 48h;

DOI:10.1055/s-0037-1610291

Reference yield: 35.0%

3-[4-amino-5-(methylthio)-4H-1,2,4-triazol-3-yl]-1-phenyl-9H-β-carboline (1085709-02-9) + 2-chloro-benzaldehyde (89-98-5) → 3-{4-[(E)-2-chlorobenzylideneamino]-5-(methylthio)-4H-1,2,4-triazol-3-yl}-1-phenyl-9H-β-carboline

Guidance literature:

In N,N-dimethyl-formamide; for 48h; Reflux;

DOI:10.1055/s-0037-1610291

upstream raw materials:

1-phenyl-3-(4-amino-5-thioxo-1,2,4-triazol-3-yl) β-carboline

methyl iodide

3-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-1-phenyl-9H-β-carboline