(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

Base Information

Chemical Name:(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid
CAS No.:1369767-18-9
Molecular Formula:C₁₇H₁₈N₂O₃
Molecular Weight:298.342
Hs Code.:

Synonyms:(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

Suppliers and Price of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

There total 10 articles about (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369767-15-6
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

: 1369767-18-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

Guidance literature:: ((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol; With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 20 ℃; for 1h;

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; acetone; at 20 ℃; for 14h;
DOI:10.1021/jm400772t

Reference yield:

: [(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenyl]cyclopropanecarbaldehyde

: 1369767-18-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; acetone; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b00217

Reference yield:

: 63106-93-4,96847-52-8,96847-75-5,96847-53-9
(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

: 1369767-18-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

2.1: lipase acrylic resin from Candida antarctica / 17 h / 20 °C / Enzymatic reaction

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / 15 h / 0 - 20 °C

3.2: 1 h / 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -60 - 20 °C

4.2: 14 h / 20 °C

With sodium tetrahydroborate; oxalyl dichloride; di-isopropyl azodicarboxylate; lipase acrylic resin from Candida antarctica; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 3.1: |Mitsunobu Displacement / 4.1: |Swern Oxidation;
DOI:10.1021/jm400772t