((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

Base Information

Chemical Name:((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol
CAS No.:1369767-15-6
Molecular Formula:C₁₇H₂₀N₂O₂
Molecular Weight:284.358
Hs Code.:

Synonyms:((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

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Chemical Property of ((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

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Technology Process of ((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

There total 8 articles about ((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.9%

: 5-(((1S,2R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-1-phenylcyclopropyl)methoxy)-2,4-dimethylpyrimidine

: 1369767-15-6
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00217

Reference yield:

: 1450905-05-1
C₁₃H₁₆O₃

: 412003-95-3
5-hydroxy-2,4-dimethylpyrimidine

: 1369767-15-6
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

Guidance literature:: C₁₃H₁₆O₃; 5-hydroxy-2,4-dimethylpyrimidine; With di-isopropyl azodicarboxylate; triphenylphosphine; at 0 - 20 ℃; for 15h;

With sodium hydroxide; In ethanol; water; at 20 ℃; for 1h;
DOI:10.1021/jm400772t

Reference yield:

: 63106-93-4,96847-52-8,96847-75-5,96847-53-9
(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

: 1369767-15-6
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

2.1: lipase acrylic resin from Candida antarctica / 17 h / 20 °C / Enzymatic reaction

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / 15 h / 0 - 20 °C

3.2: 1 h / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; lipase acrylic resin from Candida antarctica; triphenylphosphine; In tetrahydrofuran; methanol; 3.1: |Mitsunobu Displacement;
DOI:10.1021/jm400772t