N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

Base Information

Chemical Name:N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide
CAS No.:1422361-47-4
Molecular Formula:C₂₁H₂₁Cl₂F₂N₃O₅
Molecular Weight:504.318
Hs Code.:

Synonyms:N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

Suppliers and Price of N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

There total 9 articles about N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

: 5061-21-2
α-bromo-γ-butyrolactone

: 1422361-80-5
3-(4-aminobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

: 1422361-47-4
N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

Reference yield:

: 5061-21-2
α-bromo-γ-butyrolactone

: 1422361-47-4
N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

: 151103-08-1
4-difluoromethoxy-3-hydroxybenzaldehyde

: 1422361-47-4
N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 4 h / Reflux

2: sodium chlorite; aminosulfonic acid; acetic acid / water / 0.5 h / 10 °C

3: sodium hydride / tetrahydrofuran / 1 h / 10 °C

4: potassium carbonate / acetonitrile / 1.5 h / Reflux

With sodium chlorite; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.bmcl.2014.07.016