3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

Base Information

• Chemical Name: 3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
• CAS No.: 1422361-79-2
• Molecular Formula: C₁₇H₁₅BrCl₂F₂N₂O₃
• Molecular Weight: 484.125

Synonyms:3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

Chemical Property of 3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

Chemical Property:

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Technology Process of 3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

There total 7 articles about 3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichloro-4-aminopyridine (22889-78-7) + C12H12BrClF2O3 → 3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide (1422361-79-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 10 ℃; for 0.5h; Inert atmosphere;

Reference yield:

3,5-dichloro-4-aminopyridine (22889-78-7) → 3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide (1422361-79-2)

Guidance literature:

With thionyl chloride; In tetrahydrofuran; toluene;

Reference yield:

3,5-dichloro-4-aminopyridine (22889-78-7) + N-(2,6-dichlorophenyl)-3-(difluoromethoxy)-4-{3-[(2-oxotetrahydrofuran-3-yl)amino]propoxy}benzamide (1422361-78-1) → 3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide (1422361-79-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 10 ℃; for 1h;

DOI:10.1016/j.bmcl.2014.07.016

upstream raw materials:

3,5-dichloro-4-aminopyridine

3-(4-bromobutoxy)-4-(difluoromethoxy)benzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde

3,4-dihydroxybenzaldehyde

Downstream raw materials:

3-(4-aminobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)amino]butoxy}benzamide

N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

C₂₁H₂₃Cl₂F₂N₃O₆

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