methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate

Base Information

Chemical Name:methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate
CAS No.:1437778-91-0
Molecular Formula:C₂₄H₃₀FN₃O₄
Molecular Weight:443.518
Hs Code.:

Synonyms:methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate

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Chemical Property of methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate

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Technology Process of methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate

There total 14 articles about methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68886-07-7
(2-fluoro-4-hydroxylphenyl)acetic acid

: 1437778-91-0
methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; In dichloromethane;

Reference yield:

: 91361-59-0
methyl 2-(2-fluoro-4-hydroxyphenyl)acetate

: 1437778-90-9
2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol

: 1437778-91-0
methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: cis-tert-butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate

: 1437778-91-0
methyl [2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: triethylamine / ethyl acetate / 4 h / Reflux

3.1: dipotassium hydrogenphosphate; sodium carbonate / water; dimethyl sulfoxide; methanol / 7 h / 21 - 25 °C / pH 7 - 8 / Enzymatic reaction

3.2: 0.5 h / 40 °C / pH Ca_. 14

4.1: palladium on carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

5.1: caesium carbonate / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; dipotassium hydrogenphosphate; di-isopropyl azodicarboxylate; palladium on carbon; hydrogen; sodium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;