2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone

Base Information

Chemical Name:2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone
CAS No.:1437776-55-0
Molecular Formula:C₂₆H₃₃FN₄O₄
Molecular Weight:484.571
Hs Code.:

Synonyms:2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone

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Chemical Property of 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone

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Technology Process of 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone

There total 17 articles about 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68886-07-7
(2-fluoro-4-hydroxylphenyl)acetic acid

: 1437776-55-0
2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / Reflux

2: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 1 h / 20 °C

4: (E)-3-(ethyldiazenyl)-N,N-dimethylpropan-1-amine hydrochloride; triethylamine; benzotriazol-1-ol / dichloromethane / 20 °C

With di-isopropyl azodicarboxylate; sulfuric acid; (E)-3-(ethyldiazenyl)-N,N-dimethylpropan-1-amine hydrochloride; water; benzotriazol-1-ol; triethylamine; triphenylphosphine; sodium hydroxide; In methanol; dichloromethane;

Reference yield:

: 1437778-92-1
[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetic acid

: 18621-18-6
azetion-3-ol hydrochloride

: 1437776-55-0
2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone

Guidance literature:: With (E)-3-(ethyldiazenyl)-N,N-dimethylpropan-1-amine hydrochloride; benzotriazol-1-ol; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1437778-90-9
2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol

: 1437776-55-0
2-[2-fluoro-4-(2-{(1S,2R)-2-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)phenyl]-1-(3-hydroxyazetidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Inert atmosphere

2: sodium hydroxide; water / methanol / 1 h / 20 °C

3: (E)-3-(ethyldiazenyl)-N,N-dimethylpropan-1-amine hydrochloride; triethylamine; benzotriazol-1-ol / dichloromethane / 20 °C

With di-isopropyl azodicarboxylate; (E)-3-(ethyldiazenyl)-N,N-dimethylpropan-1-amine hydrochloride; water; benzotriazol-1-ol; triethylamine; triphenylphosphine; sodium hydroxide; In methanol; dichloromethane;