2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

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Chemical Name:2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one
CAS No.:1581692-13-8
Molecular Formula:C₃₂H₃₆N₈O₃
Molecular Weight:580.69
Hs Code.:

2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

Synonyms:2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

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Chemical Property of 2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

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Technology Process of 2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

There total 9 articles about 2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₈N₈O₄

: 1581692-13-8
2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 1h;

Reference yield:

: 1581692-34-3
2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzaldehyde

: 1581692-13-8
2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / dichloromethane; methanol / 0 - 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C

3: potassium acetate; palladium diacetate; XPhos / 2-methyltetrahydrofuran / 11 h / Inert atmosphere; Heating

4: XPhos; potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / Inert atmosphere; Heating

5: potassium carbonate; methanol / 1 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; potassium phosphate; potassium acetate; palladium diacetate; potassium carbonate; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; methanol; dichloromethane; water; butan-1-ol;

Reference yield:

: 1710-98-1
p-tert-butyl benzoyl chloride

: 1581692-13-8
2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethylphenyl}-6-tert-butyl-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 0 - 25 °C

2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 - -15 °C / Inert atmosphere

2.2: -78 - 0 °C

3.1: hydrazine hydrate; acetic acid / 1 h / 90 °C

4.1: potassium carbonate; tetraethylammonium chloride / N,N-dimethyl acetamide / 73 h / Inert atmosphere; Heating

5.1: sodium tetrahydroborate / dichloromethane; methanol / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; dmap / dichloromethane / 20 °C

7.1: potassium acetate; palladium diacetate; XPhos / 2-methyltetrahydrofuran / 11 h / Inert atmosphere; Heating

8.1: XPhos; potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / Inert atmosphere; Heating

9.1: potassium carbonate; methanol / 1 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; potassium phosphate; tetraethylammonium chloride; sec.-butyllithium; potassium acetate; palladium diacetate; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; cyclohexane; water; butan-1-ol;