butyl (2-bromoacetyl)-L-phenylalaninate

Base Information

• Chemical Name: butyl (2-bromoacetyl)-L-phenylalaninate
• CAS No.: 1379456-13-9
• Molecular Formula: C₁₅H₂₀BrNO₃
• Molecular Weight: 342.233
• Mol file: 1379456-13-9.mol

Synonyms:butyl (2-bromoacetyl)-L-phenylalaninate

Chemical Property of butyl (2-bromoacetyl)-L-phenylalaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl (2-bromoacetyl)-L-phenylalaninate

There total 3 articles about butyl (2-bromoacetyl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

L-Phenylalanine buthylester (2885-10-1) + 2-Bromoacetyl bromide (598-21-0) → butyl (2-bromoacetyl)-L-phenylalaninate (1379456-13-9)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 12h; Green chemistry;

DOI:10.1039/c9gc00030e

Reference yield: 79.0%

L-phenylalanine n-butyl ester hydrochloride (6330-15-0,111753-78-7) + 2-Bromoacetyl bromide (598-21-0) → butyl (2-bromoacetyl)-L-phenylalaninate (1379456-13-9)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - -20 ℃; Inert atmosphere;

DOI:10.1039/c2gc16090k

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → butyl (2-bromoacetyl)-L-phenylalaninate (1379456-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 20 °C

2: triethylamine / dichloromethane / -78 - -20 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1039/c2gc16090k

upstream raw materials:

L-phenylalanine

L-phenylalanine n-butyl ester hydrochloride

2-Bromoacetyl bromide

L-Phenylalanine buthylester

Downstream raw materials:

(S)-1-methyl-3-(2-((1-(butyloxy)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)-1H-imidazol-3-ium bromide