L-Phenylalanine butyl ester

Base Information

• Chemical Name: L-Phenylalanine butyl ester
• CAS No.: 2885-10-1
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.29500
• Mol file: 2885-10-1.mol

Synonyms:(S)-2-Amino-3-phenyl-propionic acid butyl ester;

Chemical Property of L-Phenylalanine butyl ester

Chemical Property:

• Boiling Point: 314.5±22.0 °C(Predicted)
• PKA: 7.07±0.33(Predicted)
• PSA: 52.32000
• Density: 1.042±0.06 g/cm3(Predicted)
• LogP: 2.60000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine butyl ester

There total 1 articles about L-Phenylalanine butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + butan-1-ol (71-36-3) → L-Phenylalanine buthylester (2885-10-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 12h; Reflux; Dean-Stark; Green chemistry;

DOI:10.1039/c9gc00030e

Reference yield: 95.0%

L-Phenylalanine buthylester (2885-10-1) + 2-Bromoacetyl bromide (598-21-0) → butyl (2-bromoacetyl)-L-phenylalaninate (1379456-13-9)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 12h; Green chemistry;

DOI:10.1039/c9gc00030e

Reference yield: 45.0%

oxalyl dichloride (79-37-8) + L-Phenylalanine buthylester (2885-10-1) → dibutyl (2S,7S)-3,6-diaza-4,5-dioxo-2,7-dibenzyloctano-1,8-dicarboxylate

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; for 12h; Ambient temperature;

DOI:10.1016/0223-5234(94)90025-6

upstream raw materials:

L-phenylalanine

butan-1-ol

Downstream raw materials:

butyl (2-bromoacetyl)-L-phenylalaninate