3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide

Base Information

• Chemical Name: 3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide
• CAS No.: 1534330-27-2
• Molecular Formula: C₂₀H₁₈ClN₅O
• Molecular Weight: 379.849

Synonyms:3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide

Chemical Property of 3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide

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Technology Process of 3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide

There total 1 articles about 3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-amino-5,7-diphenyl-4,7-dihydro-1,2,4-triazolo<1,5-a>pyrimidine (134834-75-6) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide (1534330-27-2)

Guidance literature:

With pyridine; In acetonitrile; at 0 - 5 ℃; for 0.5h;

DOI:10.1016/j.tet.2013.11.090

Reference yield: 28.0%

3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide (1534330-27-2) → 8-oxo-2,4-diphenyl-1,4,7,8,9,10-hexahydro[1,2,4]triazolo[1,5-a:4,3-a']dipyrimidin-5-ium chloride (1534330-30-7)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 90 ℃; for 0.05h;

DOI:10.1016/j.tet.2013.11.090

Reference yield:

3-chloro-N-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanamide (1534330-27-2) → 8-oxo-2,4-diphenyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-a:4,3-a']dipyrimidin-5-ium chloride (1534330-36-3)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 90 ℃; for 8h;

DOI:10.1016/j.tet.2013.11.090

upstream raw materials:

2-amino-5,7-diphenyl-4,7-dihydro-1,2,4-triazolo<1,5-a>pyrimidine

2-chloropropionyl chloride

Downstream raw materials:

8-oxo-2,4-diphenyl-9,10-dihydro-8H-[1,2,4]triazolo[1,5-a:4,3-a']dipyrimidin-5-ium-7-ide

C₂₀H₁₇N₅O

8-oxo-2,4-diphenyl-1,4,7,8,9,10-hexahydro[1,2,4]triazolo[1,5-a:4,3-a']dipyrimidin-5-ium chloride

8-oxo-2,4-diphenyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-a:4,3-a']dipyrimidin-5-ium chloride

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