N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one

Base Information

Chemical Name:N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one
CAS No.:138384-58-4
Molecular Formula:C₂₃H₂₂ClN₃O₄S
Molecular Weight:471.964
Hs Code.:

N<sup>6</sup>-<4-(morpholinosulfonyl)benzyl>-N<sup>6</sup>-methyl-6-amino-5-chlorobenz<cd>indol-2(1H)-one

Synonyms:N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one

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Technology Process of N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one

There total 8 articles about N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 138385-01-0
N⁶-<4-(morpholinosulfonyl)benzyl>-6-amino-5-chlorobenzindol-2(1H)-one

: 74-88-4
methyl iodide

: 138384-58-4
N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; a) 65 deg C, 8 h, b) 25 deg C, 18 h;
DOI:10.1021/jm00082a006

Reference yield:

: 74356-38-0
5-aminobenzindol-2(1H)-one

: 138384-58-4
N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / CuCl₂, tert-butyl nitrite / acetonitrile / 2 h / 25 °C

2: 71 percent / conc. H₂SO₄, conc. HNO₃ / 3 h / 0 °C

3: 60 percent / SnCl₂*2H₂O / ethanol / 3 h / 60 °C

4: 87 percent / DIEA / dimethylformamide / 4.25 h / 85 °C

5: 55 percent / DIEA / dimethylformamide / a) 65 deg C, 8 h, b) 25 deg C, 18 h

With tert.-butylnitrite; sulfuric acid; nitric acid; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; copper dichloride; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a006

Reference yield:

: 24950-29-6
5-chlorobenzindol-2(1H)-one

: 138384-58-4
N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / conc. H₂SO₄, conc. HNO₃ / 3 h / 0 °C

2: 60 percent / SnCl₂*2H₂O / ethanol / 3 h / 60 °C

3: 87 percent / DIEA / dimethylformamide / 4.25 h / 85 °C

4: 55 percent / DIEA / dimethylformamide / a) 65 deg C, 8 h, b) 25 deg C, 18 h

With sulfuric acid; nitric acid; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a006