Chemical Property of 3-Iodo-2-propynyl butylcarbamate
Chemical Property:
- Appearance/Colour:Off-white solid
- Vapor Pressure:0.005Pa at 25℃
- Melting Point:64-68 °C(lit.)
- Refractive Index:1.546
- Boiling Point:321.8 °C at 760 mmHg
- PKA:12.03±0.46(Predicted)
- Flash Point:148.4 °C
- PSA：38.33000
- Density:1.606 g/cm3
- LogP:2.29950
- Storage Temp.:Refrigerator
- Solubility.:soluble in Methanol
- Water Solubility.:168mg/L at 20℃
- XLogP3:2.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:5
- Exact Mass:280.99128
- Heavy Atom Count:12
- Complexity:192
- Transport DOT Label:Class 9
- Purity/Quality:
-
99% *data from raw suppliers
3-Iodo-2-propynyl N-butylcarbamate
*data from reagent suppliers
Safty Information:
- Pictogram(s):
N
- Hazard Codes:N
- Statements:
50/53-50
- Safety Statements:
60-61-29
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Uses -> Biocides/Disinfectants
- Canonical SMILES:CCCCNC(=O)OCC#CI
- Recent ClinicalTrials:Treatment of Chronic Fatigue Syndrome (CFS) With Iodinated Activated Charcoal (IodoCarb?)
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Description
Iodopropynyl butylcarbamate is a preservative that has been used as an industrial fungicide since the 1970s and more recently has been combined with formaldehydereleasing agents for use in cosmetics. The North American Contact Dermatitis Group patch tested with 0.1%iodopropynyl butylcarbamate in petrolatum and found 0.2% of their patch test clinic patients had positive reactions to this chemical. Most cosmetic applications appear to require less than 0.012% of this preservative.
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Uses
Glycacil(R) 2000 is used as a preservative in personal care formulations. Glycacil(R) L is used as a preservative in personal care formulations. Glycacil(R) S is used as a preservative in personal care formulations. An antibacterial agent. Fungicide; mildewcide; preservative in cosmetics, paints and coatings, metal working fluids; wood protection. iodopropynyl butylcarbamate is a preservative with broad fungicidal activity used in skin care products. It is recommended for use in difficult formulation systems.
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Clinical Use
Iodopropynyl butylcarbamate (3-iodo-2-propynyl-butylcarbamate) is a highly effective fungicide as well as a bactericide. It was first used in the 1970s as a film fungicide for paint and then as a wood preservative, where final use concentration up to 4% was permitted. For paint and coatings usually no more than 0.5% iodopropynyl butylcarbamate is used. For metalworking fluids, adhesives, textiles, and paper, concentrations between 0.1%and 0.2% are common. The Cosmetic Ingredient Review Expert Panel concluded that iodopropynyl butylcarbamate is safe as a cosmetic ingredient in concentrations less than or equal to 0.1%and that it should not be used in products intended to be aerosolized. By 1996, iodopropynyl butylcarbamate was used in 122 formulations reported to the United States Food and Drug Administration. Iodopropynyl butylcarbamate is found in a wide variety of occupational and consumer products, including shampoos, lotions, powders, makeup, baby products, paints, coatings, metalworking fluids, household products, cooling water, building materials, and contact lenses. It is an irritant, although at low concentrations few problems have been reported.
