4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

Base Information

Chemical Name:4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide
CAS No.:1274816-84-0
Molecular Formula:C₂₆H₂₁F₃N₄O₃
Molecular Weight:494.473
Hs Code.:

Synonyms:4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

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Chemical Property of 4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

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Technology Process of 4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

There total 6 articles about 4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1274816-79-3
7-((2-[(methylamino)carbonyl]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1274816-84-0
4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm101479y

Reference yield:

: 6836-19-7
7-Methoxy-1-tetralone

: 1274816-84-0
4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 65 °C

1.2: 3.17 h / 65 °C

2.1: palladium 10% on activated carbon; sulfuric acid; hydrogen; acetic acid / 2.5 h / 1551.49 Torr

3.1: hydrogen bromide; acetic acid / 100 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 100 °C

4.2: pH 3

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sulfuric acid; palladium 10% on activated carbon; hydrogen bromide; hydrogen; sodium hydride; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm101479y

Reference yield:

: 31846-36-3
7-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

: 1274816-84-0
4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 100 °C

1.2: pH 3

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101479y