4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride

Base Information

Chemical Name:4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride
CAS No.:1313494-65-3
Molecular Formula:C₂₆H₂₅F₃N₄O₃*ClH
Molecular Weight:534.966
Hs Code.:

4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride

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Chemical Property of 4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride

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Technology Process of 4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride

There total 7 articles about 4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1274816-84-0
4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide

: 1313494-65-3
4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride

Guidance literature:: 4-([7-(([4-cyano-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide; With ammonia; hydrogen; In methanol; water; for 5h;

With hydrogenchloride; In diethyl ether; dichloromethane;
DOI:10.1021/jm101479y

Reference yield:

: 1274816-79-3
7-((2-[(methylamino)carbonyl]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

: 1313494-65-3
4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: ammonia; hydrogen / methanol; water / 5 h

With dmap; ammonia; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1021/jm101479y

Reference yield:

: 6836-19-7
7-Methoxy-1-tetralone

: 1313494-65-3
4-([7-(([4-(aminomethyl)-3-(trifluoromethyl)phenyl]amino)carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy)-N-methylpyridine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 65 °C

1.2: 3.17 h / 65 °C

2.1: palladium 10% on activated carbon; sulfuric acid; hydrogen; acetic acid / 2.5 h / 1551.49 Torr

3.1: hydrogen bromide; acetic acid / 100 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 100 °C

4.2: pH 3

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

6.1: ammonia; hydrogen / methanol; water / 5 h

With dmap; sulfuric acid; palladium 10% on activated carbon; ammonia; hydrogen bromide; hydrogen; sodium hydride; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm101479y