(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

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Chemical Name:(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate
CAS No.:1378532-43-4
Molecular Formula:C₃₃H₃₃F₆NO₆
Molecular Weight:653.619
Hs Code.:

(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

Synonyms:(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

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Chemical Property of (2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

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Technology Process of (2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

There total 8 articles about (2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1378532-34-3
(+)-(2S,3S)-1-benzyl-3-hydroxypiperidine-2-methanol

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1378532-43-4
(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

Guidance literature:: (+)-(2S,3S)-1-benzyl-3-hydroxypiperidine-2-methanol; (R)-methoxytrifluoromethylphenylacetyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With silica gel; In diethyl ether; hexane;
DOI:10.1002/hlca.201100507

Reference yield:

: 27230-48-4,105888-88-8,146937-08-8
3-hydroxy-2-hydroxymethylpiperidine

: 1378532-43-4
(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / ethanol / Reflux

2.1: pyridine / -20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 °C

4.1: sodium tetrahydroborate / ethanol / -15 °C

4.2: -15 - 20 °C

5.1: Chiralcel_.(R). OD / hexane; isopropyl alcohol

6.1: water; potassium hydroxide / ethanol / 3 h / 20 °C

7.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; oxalyl dichloride; water; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hydroxide; In ethanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1002/hlca.201100507

Reference yield:

: C₂₀H₂₉NO₄

: 1378532-43-4
(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

Guidance literature:: Multi-step reaction with 4 steps

1: silica gel / hexane; ethyl acetate

2: Chiralcel_.(R). OD / hexane; isopropyl alcohol

3: water; potassium hydroxide / ethanol / 3 h / 20 °C

4: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; water; silica gel; triethylamine; potassium hydroxide; In ethanol; hexane; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1002/hlca.201100507