2-(Hydroxymethyl)piperidin-3-ol

Base Information

Chemical Name:2-(Hydroxymethyl)piperidin-3-ol
CAS No.:27230-48-4
Molecular Formula:C₆H₁₃NO₂
Molecular Weight:131.175
Hs Code.:
NSC Number:87546
DSSTox Substance ID:DTXSID10949951

Synonyms:2-(hydroxymethyl)piperidin-3-ol;27230-48-4;NSC87546;starbld0028034;SCHEMBL980572;DTXSID10949951;WRLZCUCTSFUOQY-UHFFFAOYSA-N;NSC-87546;AKOS006353487;SB47590;(2RS,3RS)-2-hydroxymethyl-piperidin-3-ol;FT-0755662

Suppliers and Price of 2-(Hydroxymethyl)piperidin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-(Hydroxymethyl)piperidin-3-ol

Chemical Property:

Vapor Pressure:0.000565mmHg at 25°C
Boiling Point:277.2°C at 760 mmHg
Flash Point:148.1°C
Density:1.111g/cm³
XLogP3:-0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:131.094628657
Heavy Atom Count:9
Complexity:87.1

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C(NC1)CO)O

Technology Process of 2-(Hydroxymethyl)piperidin-3-ol

There total 1 articles about 2-(Hydroxymethyl)piperidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14047-53-1
3-hydroxy-2-hydroxymethylpyridine

: 27230-48-4,105888-88-8,146937-08-8
3-hydroxy-2-hydroxymethylpiperidine

Guidance literature:: With hydrogen; In water; at 35 ℃; under 45004.5 Torr; pH=3;
DOI:10.1002/hlca.201100507

Reference yield:

: 27230-48-4,105888-88-8,146937-08-8
3-hydroxy-2-hydroxymethylpiperidine

: 1378532-42-3
(2S,3S)-1-(phenylmethyl)-2-{[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αR)-α-methoxy-α-(trifluoromethyl)benzeneacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / ethanol / Reflux

2.1: pyridine / -20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 °C

4.1: sodium tetrahydroborate / ethanol / -15 °C

4.2: -15 - 20 °C

5.1: Chiralcel_.(R). OD / hexane; isopropyl alcohol

6.1: water; potassium hydroxide / ethanol / 3 h / 20 °C

7.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; oxalyl dichloride; water; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hydroxide; In ethanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1002/hlca.201100507

Reference yield:

: 27230-48-4,105888-88-8,146937-08-8
3-hydroxy-2-hydroxymethylpiperidine

: 1378532-43-4
(2S,3S)-1-(phenylmethyl)-2-{[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]methyl}piperidin-3-yl (αS)-α-methoxy-α-(trifluoromethyl)benzeneacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / ethanol / Reflux

2.1: pyridine / -20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 °C

4.1: sodium tetrahydroborate / ethanol / -15 °C

4.2: -15 - 20 °C

5.1: Chiralcel_.(R). OD / hexane; isopropyl alcohol

6.1: water; potassium hydroxide / ethanol / 3 h / 20 °C

7.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; oxalyl dichloride; water; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium hydroxide; In ethanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1002/hlca.201100507