1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate
• CAS No.: 334477-33-7
• Molecular Formula: C₁₆H₂₃FN₂O₂
• Molecular Weight: 294.369

Synonyms:1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate

Chemical Property of 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate

There total 1 articles about 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (2S)-2-(4-fluoro-2-methylphenyl)piperazine dihydrochloride (334477-59-7,1434126-86-9) → 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate (334477-33-7) + bis(1,1-dimethylethyl) (2S)-2-(4-fluoro-2-methylphenyl)-1,4-piperazinedicarboxylate (1192874-45-5)

Guidance literature:

(2S)-2-(4-fluoro-2-methylphenyl)piperazine dihydrochloride; With triethylamine; In ethyl acetate; at 40 ℃; for 2h;

di-tert-butyl dicarbonate; In ethyl acetate; at 20 ℃; for 1.75h;

DOI:10.1021/op9002032

Reference yield: 56.0%

bis(trichloromethyl) carbonate (32315-10-9) + 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate (334477-33-7) + 2-(3,5-bis(trifluoromethyl)phenyl)-1-(naphthalen-2-ylsulfonyl)pyrrolidine (334477-36-0,1213591-33-3,1213914-71-6) → C29H32F7N3O3 (1208864-79-2)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 7h; Reflux;

DOI:10.1016/j.bmcl.2009.11.078

Reference yield: 40.0%

bis(trichloromethyl) carbonate (32315-10-9) + 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate (334477-33-7) + C17H20F6N2O2 (1060807-74-0) → C34H41F7N4O5 (1208864-93-0)

Guidance literature:

With triethylamine; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2009.11.078

upstream raw materials:

di-tert-butyl dicarbonate

(2S)-2-(4-fluoro-2-methylphenyl)piperazine dihydrochloride

Downstream raw materials:

1,1-dimethylethyl (3S)-4-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate

(2S)-N,N-diethyl-2-(4-fluoro-2-methylphenyl)-1-piperazinecarboxamide

N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N',N'-diethyl-N-methylurea

N,N'-bis{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N,N'-dimethylurea

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 334477-33-7 1,1-dimethylethyl (3S)-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send