methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate

Base Information

• Chemical Name: methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate
• CAS No.: 1280722-73-7
• Molecular Formula: C₂₂H₂₁NO₄
• Molecular Weight: 363.413
• Mol file: 1280722-73-7.mol

Synonyms:methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate

Chemical Property of methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate

There total 1 articles about methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-methylindole (603-76-9) + methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate (1258518-10-3) → methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate (1280722-73-7)

Guidance literature:

1-methylindole; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol200305n

Reference yield:

methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate (1280722-73-7) → methyl 4-(4-methoxyphenyl)-9-methyl-1-oxo-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate + methyl 4-(4-methoxyphenyl)-9-methyl-1-oxo-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate

Guidance literature:

With indium(III) triflate; In dichloromethane; at 25 ℃; for 5.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol200305n

upstream raw materials:

1-methylindole

methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate