methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate

Base Information

• Chemical Name: methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate
• CAS No.: 1258518-10-3
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 1258518-10-3.mol

Synonyms:methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate

Chemical Property of methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate

There total 1 articles about methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-Methoxystyrene (637-69-4,24936-44-5) + methyl 2-diazo-3-(methoxy(methyl)amino)-3-oxopropanoate (1198573-72-6) → methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate (1258518-10-3)

Guidance literature:

With rhodium (II) octanoate dimer; In dichloromethane; for 36h; Inert atmosphere;

DOI:10.1021/ol102497w

Reference yield: 70.0%

methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate (1258518-10-3) + isopropenylmagnesium bromide (13291-18-4) → methyl 1-methacryloyl-2-(4-methoxyphenyl)cyclopropane-1-carboxylate (1258517-97-3)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol102497w

Reference yield: 68.0%

1-methylindole (603-76-9) + methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate (1258518-10-3) → methyl 2-(4-methoxyphenyl)-1-(1-methyl-1H-indole-2-carbonyl)cyclopropanecarboxylate (1280722-73-7)

Guidance literature:

1-methylindole; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

methyl 1-(methoxy(methyl)carbamoyl)-2-(4-methoxyphenyl)cyclopropane-1-carboxylate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol200305n

upstream raw materials:

4-Methoxystyrene

methyl 2-diazo-3-(methoxy(methyl)amino)-3-oxopropanoate

Downstream raw materials:

methyl 1-(3,4-dihydro-2H-pyran-6-carbonyl)-2-(4-methoxyphenyl)cyclopropanecarboxylate

methyl 1-(cyclohex-1-enecarbonyl)-2-(4-methoxyphenyl)cyclopropanecarboxylate

methyl 4-(4-methoxyphenyl)-1-oxo-1,2,3,4,5,6,7,8-octahydronaphthalene-2-carboxylate

methyl 5-(4-methoxyphenyl)-3,4-dimethyl-2-oxoyclohex-3-enecarboxylate