3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

Base Information

Chemical Name:3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid
CAS No.:1290047-66-3
Molecular Formula:C₁₅H₁₇Cl₂N₃O₄
Molecular Weight:374.224
Hs Code.:

Synonyms:3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

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Technology Process of 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

There total 8 articles about 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1290047-69-6
3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid tert-butyl ester

: 1290047-66-3
3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1205543-12-9
(S)-2-[benzyloxycarbonyl-(2-oxo-ethyl)-amino]-propionic acid methyl ester

: 1290047-66-3
3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 1 h

3: triethylamine / dichloromethane / 0.5 h / 0 °C

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 - 20 °C

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1290047-67-4
(S)-4-(2-tert-butoxycarbonyl-ethyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester

: 1290047-66-3
3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 1 h

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 - 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water;