(S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

Base Information

Chemical Name:(S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide
CAS No.:1290049-14-7
Molecular Formula:C₂₂H₂₈Cl₂N₄O₄
Molecular Weight:483.395
Hs Code.:

Synonyms:(S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

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Chemical Property of (S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

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Technology Process of (S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

There total 18 articles about (S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1103501-89-8,955028-68-9
(S)-6-aza-spiro[2.5]octan-4-ol hydrochloride

: 1290047-66-3
3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid

: 1290049-14-7
(S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 159635-22-0
3-hydroxy-4-methylene-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

: 1290049-14-7
(S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylzinc / toluene; 1,2-dichloro-ethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -70 - -60 °C

2.2: 0.17 h / -60 °C

3.1: sodium hydroxide; magnesium(II) chloride hexahydrate; α-D-glucose monohydrate / ketoreductase KRED-NADH-117; glucose dehydrogenase GDH-102 / 35 °C / pH 6.5 / Aqueous buffer

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 1 h / 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0 °C

With hydrogenchloride; oxalyl dichloride; magnesium(II) chloride hexahydrate; diethylzinc; α-D-glucose monohydrate; dimethyl sulfoxide; triethylamine; HATU; sodium hydroxide; ketoreductase KRED-NADH-117; glucose dehydrogenase GDH-102; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 2.1: Swern Oxidation / 2.2: Swern Oxidation;

Reference yield:

: 1101840-72-5
tert-butyl 4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate

: 1290049-14-7
(S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -70 - -60 °C

1.2: 0.17 h / -60 °C

2.1: sodium hydroxide; magnesium(II) chloride hexahydrate; α-D-glucose monohydrate / ketoreductase KRED-NADH-117; glucose dehydrogenase GDH-102 / 35 °C / pH 6.5 / Aqueous buffer

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 1 h / 20 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0 °C

With hydrogenchloride; oxalyl dichloride; magnesium(II) chloride hexahydrate; α-D-glucose monohydrate; dimethyl sulfoxide; triethylamine; HATU; sodium hydroxide; ketoreductase KRED-NADH-117; glucose dehydrogenase GDH-102; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Swern Oxidation / 1.2: Swern Oxidation;