(S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

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Chemical Name:(S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol
CAS No.:120341-89-1
Molecular Formula:C₄₀H₆₀O₆S₂Si
Molecular Weight:729.13
Hs Code.:

(S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

Synonyms:(S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

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Chemical Property of (S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

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Technology Process of (S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

There total 13 articles about (S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125975-53-3,147220-48-2,116996-54-4
(2S)-O-(tert-butyldiphenylsilyl)-1,2-epoxybutan-4-ol

: 120341-89-1
(S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) THF, -20 deg C, 2 h, 2.) 17 h

2: 78 percent / NBS, AgNO₃, 2,6-lutidine / H₂O; acetonitrile / 0.12 h

3: LiAlH₄, LiI / diethyl ether / 0.5 h / -100 °C

4: 93 percent / PPTS / CH₂Cl₂ / 7 h

5: 42 percent / acetic acid; tetrahydrofuran / 48 h / -10 °C

6: pyridine / 3 h / 0 °C

7: KH / diethyl ether; methanol / 0.33 h / 0 °C

8: 1.) n-BuLi / 1.) THF, -20 deg C, 2h, 2.) 9 h

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; pyridinium p-toluenesulfonate; potassium hydride; silver nitrate; lithium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1016/S0040-4039(00)82885-3

Reference yield:

: 116996-52-2
(2S)-4-O-(tert-butyldiphenylsilyl)butane-1,2,4-triol

: 120341-89-1
(S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine

2: K₂CO₃ / methanol

3: 1.) n-BuLi / 1.) THF, -20 deg C, 2 h, 2.) 17 h

4: 78 percent / NBS, AgNO₃, 2,6-lutidine / H₂O; acetonitrile / 0.12 h

5: LiAlH₄, LiI / diethyl ether / 0.5 h / -100 °C

6: 93 percent / PPTS / CH₂Cl₂ / 7 h

7: 42 percent / acetic acid; tetrahydrofuran / 48 h / -10 °C

8: pyridine / 3 h / 0 °C

9: KH / diethyl ether; methanol / 0.33 h / 0 °C

10: 1.) n-BuLi / 1.) THF, -20 deg C, 2h, 2.) 9 h

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; pyridinium p-toluenesulfonate; potassium hydride; potassium carbonate; silver nitrate; lithium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1016/S0040-4039(00)82885-3

Reference yield:

: 32233-44-6
2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde

: 120341-89-1
(S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / BF₃OEt₃ / CH₂Cl₂

2: 1.) n-BuLi / 1.) THF, -20 deg C, 2h, 2.) 9 h

With n-butyllithium; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/S0040-4039(00)82885-3