tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane
CAS No.:120341-92-6
Molecular Formula:C₄₃H₆₄O₇Si
Molecular Weight:721.062
Hs Code.:

tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

Synonyms:tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

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Chemical Property of tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

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Technology Process of tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

There total 17 articles about tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 933-40-4
cycloxexanone dimethyl ketal

: 120341-91-5
(2R,4S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentane-2,4-diol

: 120341-92-6
tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 7h;
DOI:10.1016/S0040-4039(00)82885-3

Reference yield:

: 116996-52-2
(2S)-4-O-(tert-butyldiphenylsilyl)butane-1,2,4-triol

: 120341-92-6
tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 13 steps

1: pyridine

2: K₂CO₃ / methanol

3: 1.) n-BuLi / 1.) THF, -20 deg C, 2 h, 2.) 17 h

4: 78 percent / NBS, AgNO₃, 2,6-lutidine / H₂O; acetonitrile / 0.12 h

5: LiAlH₄, LiI / diethyl ether / 0.5 h / -100 °C

6: 93 percent / PPTS / CH₂Cl₂ / 7 h

7: 42 percent / acetic acid; tetrahydrofuran / 48 h / -10 °C

8: pyridine / 3 h / 0 °C

9: KH / diethyl ether; methanol / 0.33 h / 0 °C

10: 1.) n-BuLi / 1.) THF, -20 deg C, 2h, 2.) 9 h

11: 69 percent / NBS, AgNO₃, 2,6-lutidine / H₂O; acetonitrile / 0.12 h

12: LiAlH₄, LiI / diethyl ether / 30 h / -100 °C

13: 88 percent / PPTS / CH₂Cl₂ / 7 h

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; pyridinium p-toluenesulfonate; potassium hydride; potassium carbonate; silver nitrate; lithium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1016/S0040-4039(00)82885-3

Reference yield:

: 125975-53-3,147220-48-2,116996-54-4
(2S)-O-(tert-butyldiphenylsilyl)-1,2-epoxybutan-4-ol

: 120341-92-6
tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) n-BuLi / 1.) THF, -20 deg C, 2 h, 2.) 17 h

2: 78 percent / NBS, AgNO₃, 2,6-lutidine / H₂O; acetonitrile / 0.12 h

3: LiAlH₄, LiI / diethyl ether / 0.5 h / -100 °C

4: 93 percent / PPTS / CH₂Cl₂ / 7 h

5: 42 percent / acetic acid; tetrahydrofuran / 48 h / -10 °C

6: pyridine / 3 h / 0 °C

7: KH / diethyl ether; methanol / 0.33 h / 0 °C

8: 1.) n-BuLi / 1.) THF, -20 deg C, 2h, 2.) 9 h

9: 69 percent / NBS, AgNO₃, 2,6-lutidine / H₂O; acetonitrile / 0.12 h

10: LiAlH₄, LiI / diethyl ether / 30 h / -100 °C

11: 88 percent / PPTS / CH₂Cl₂ / 7 h

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; pyridinium p-toluenesulfonate; potassium hydride; silver nitrate; lithium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1016/S0040-4039(00)82885-3