5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

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Chemical Name:5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole
CAS No.:1567335-76-5
Molecular Formula:C₃₂H₃₆N₂O₃
Molecular Weight:496.649
Hs Code.:

Synonyms:5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

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Chemical Property of 5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

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Technology Process of 5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

There total 7 articles about 5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

: 1567335-34-5
trifluoromethanesulfonic acid 2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-2H-pyrazol-3-yl ester

: 146631-00-7
[4-(benzyloxy)phenyl]boronic acid

: 1567335-76-5
5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 80 ℃; for 6h;

Reference yield:

: 1197-66-6
2,2,6,6-tetramethyltetrahydropyran-4-one

: 1567335-76-5
5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / tert-butyl alcohol; 1,2-dimethoxyethane / 0 - 35 °C / Reflux

2: thionyl chloride / dichloromethane / 8 h / 20 °C

3: magnesium bromide diethyl etherate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: ethanol / 4 h / 80 °C

5: triethylamine / 1,2-dichloro-ethane / 2 h / 60 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 6 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; magnesium bromide diethyl etherate; potassium tert-butylate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene; tert-butyl alcohol;

Reference yield:

: 1567335-32-3
3-oxo-3-(2,2,6,6-tetramethyltetrahydropyran-4-yl)thiopropionic acid S-phenyl ester

: 1567335-76-5
5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 4 h / 80 °C

2: triethylamine / 1,2-dichloro-ethane / 2 h / 60 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 6 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In ethanol; 1,2-dichloro-ethane; toluene;