(±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone

Base Information

Chemical Name:(±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone
CAS No.:1614264-91-3
Molecular Formula:C₁₈H₁₉ClN₂O₇
Molecular Weight:410.811
Hs Code.:

Synonyms:(±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone

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Chemical Property of (±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone

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Technology Process of (±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone

There total 5 articles about (±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 61644-18-6
chloromethyl isobutyrate

: 1614264-76-4
(±)-5-carboxy-4-(2-chloro-5-nitrophenyl)-6-methyl-3,4-dihydro-2(1H)-pyridone

: 1614264-91-3
(±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone

Guidance literature:: (±)-5-carboxy-4-(2-chloro-5-nitrophenyl)-6-methyl-3,4-dihydro-2(1H)-pyridone; With caesium carbonate; In N,N-dimethyl-formamide;

chloromethyl isobutyrate; In N,N-dimethyl-formamide; at 20 ℃; for 23h;
DOI:10.1016/j.tet.2014.05.012

Reference yield:

: 6361-21-3
2-chloro-5-nitrobenzaldehyde

: 1614264-91-3
(±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; ammonium acetate / 5 h / 80 °C / Reflux

2.1: trifluoroacetic acid / dichloromethane / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide

3.2: 23 h / 20 °C

With ammonium acetate; caesium carbonate; acetic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.012

Reference yield:

: 1614264-72-0
(±)-4-(2-chloro-5-nitrophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

: 1614264-91-3
(±)-4-(2-chloro-5-nitrophenyl)-6-methyl-5-[(2-methylpropanoyloxy)methyloxycarbonyl]-3,4-dihydro-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / acetone / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide

2.2: 23 h / 20 °C

With water; caesium carbonate; sodium hydroxide; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2014.05.012