Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid methyl ester

Base Information

• Chemical Name: Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid methyl ester
• CAS No.: 85727-15-7
• Molecular Formula: C₁₁H₁₂ClNO₅S
• Molecular Weight: 305.739
• Mol file: 85727-15-7.mol

Synonyms:Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid methyl ester

Chemical Property of Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid methyl ester

There total 1 articles about Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylsaccharin (15448-99-4) + methyl chloroacetate (96-34-4) → Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl)-acetic acid methyl ester (85727-15-7) + methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-15-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 40 - 50 ℃; for 2h; Yield given;

DOI:10.1021/jo00168a060

Reference yield: 80.0%

Chloro-(3-hydroxy-2-methyl-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl)-acetic acid methyl ester (85727-15-7) → methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-15-0)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 34 ℃; for 1.5h;

DOI:10.1021/jo00168a060

upstream raw materials:

N-methylsaccharin

methyl chloroacetate

Downstream raw materials:

methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide