N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

Base Information

Chemical Name:N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide
CAS No.:1402850-53-6
Molecular Formula:C₁₈H₁₈ClNO₃S
Molecular Weight:363.865
Hs Code.:

Synonyms:N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

Chemical Property:

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Technology Process of N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

There total 3 articles about N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333483-14-9
N-methyll-N-(phenylethylnyl)methanesulfonamide

: 2788-86-5,53649-47-1,97466-49-4,21019-51-2
(R)-2-(4-chlorophenyl)oxirane

: N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

: 1402850-53-6
N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver(I) triflimide; In dichloromethane; at 0 ℃; for 4h; optical yield given as %ee; enantiospecific reaction; Inert atmosphere;
DOI:10.1002/anie.201203723

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

: 1402850-53-6
N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: AD-mix-β; water / tert-butyl alcohol / 4 h / 0 °C / Inert atmosphere

2.1: Trimethyl orthoacetate; chloro-trimethyl-silane / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 1.6 h / Inert atmosphere

3.1: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver(I) triflimide / dichloromethane / 4 h / 0 °C / Inert atmosphere

With Trimethyl orthoacetate; AD-mix-β; chloro-trimethyl-silane; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); water; silver(I) triflimide; In dichloromethane; tert-butyl alcohol;
DOI:10.1002/anie.201203723

Reference yield:

: 152142-03-5
(1R)-1-(4-chlorophenyl)-1,2-ethanediol

: N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

: 1402850-53-6
N-(5-(4-chlorophenyl)-4,5-dihydrobenzo[d]oxepin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Trimethyl orthoacetate; chloro-trimethyl-silane / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 1.6 h / Inert atmosphere

2.1: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver(I) triflimide / dichloromethane / 4 h / 0 °C / Inert atmosphere

With Trimethyl orthoacetate; chloro-trimethyl-silane; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver(I) triflimide; In dichloromethane;
DOI:10.1002/anie.201203723