Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

Base Information

Chemical Name:Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester
CAS No.:476443-71-7
Molecular Formula:C₂₃H₂₅NO₆
Molecular Weight:411.455
Hs Code.:

Synonyms:Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

Suppliers and Price of Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

There total 3 articles about Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 476443-56-8
(Z)-2-Bromo-6-methoxy-1-methoxymethoxy-hex-2-en-4-yne

: methoxy-acetic acid 1-cyano-1-phenyl-but-3-ynyl ester

: 476443-71-7
Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

Guidance literature:: With copper(l) iodide; diethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 60 ℃;
DOI:10.1016/S0040-4039(02)01529-0

Reference yield:

: 476443-72-8
(Z)-2-Bromo-6-methoxy-hex-2-en-4-ynoic acid ethyl ester

: 476443-71-7
Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / DIBALH / tetrahydrofuran / -78 °C

2: 93 percent / DIEA / CH₂Cl₂ / Heating

3: 74 percent / CuI; Et₂NH / Pd(PPh₃)4 / toluene / 60 °C

With copper(l) iodide; diisobutylaluminium hydride; diethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; 3: Sonogashira cross coupling;
DOI:10.1016/S0040-4039(02)01529-0

Reference yield:

: 476443-55-7
(Z)-2-Bromo-6-methoxy-hex-2-en-4-yn-1-ol

: 476443-71-7
Methoxy-acetic acid (E)-1-cyano-9-methoxy-5-methoxymethoxymethyl-1-phenyl-non-5-ene-3,7-diynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / DIEA / CH₂Cl₂ / Heating

2: 74 percent / CuI; Et₂NH / Pd(PPh₃)4 / toluene / 60 °C

With copper(l) iodide; diethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; 2: Sonogashira cross coupling;
DOI:10.1016/S0040-4039(02)01529-0