N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide

Base Information

Chemical Name:N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide
CAS No.:951173-47-0
Molecular Formula:C₂₁H₂₁N₃OS₂
Molecular Weight:395.549
Hs Code.:

Synonyms:N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide

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Chemical Property of N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide

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Technology Process of N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide

There total 7 articles about N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 951173-46-9
(Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

: 951173-47-0
N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide

Guidance literature:: With Lawessons reagent; In toluene; at 100 ℃; for 3.5h;
DOI:10.1016/j.tet.2007.06.089

Reference yield:

: 930304-05-5
1-benzyloxymethyl-2-methylsulfanylimidazole-4-carbaldehyde

: 951173-47-0
N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butoxide / tetrahydrofuran / 0.08 h / 20 °C

1.2: 93 percent / tetrahydrofuran / 0.5 h / -78 °C

2.1: 99 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 15 h / 70 °C

3.1: 95 percent / Lawesson's reagent / toluene / 3.5 h / 100 °C

With Lawessons reagent; copper(l) iodide; potassium tert-butylate; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; toluene; 1.1: Stork-Zhao Wittig reaction / 2.1: Buchwald coupling;
DOI:10.1016/j.tet.2007.06.089

Reference yield:

: 930304-06-6
(Z)-1-benzyloxymethyl-4-(2-iodovinyl)-2-methylsulfanylimidazole

: 951173-47-0
N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)-vinyl]thiobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 15 h / 70 °C

2: 95 percent / Lawesson's reagent / toluene / 3.5 h / 100 °C

With Lawessons reagent; copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; toluene; 1: Buchwald coupling;
DOI:10.1016/j.tet.2007.06.089