(Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

Base Information

Chemical Name:(Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide
CAS No.:951173-46-9
Molecular Formula:C₂₁H₂₁N₃O₂S
Molecular Weight:379.483
Hs Code.:

Synonyms:(Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

Chemical Property:

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Technology Process of (Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

There total 6 articles about (Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 930304-06-6
(Z)-1-benzyloxymethyl-4-(2-iodovinyl)-2-methylsulfanylimidazole

: 55-21-0,27208-38-4
benzamide

: 951173-46-9
(Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; at 70 ℃; for 15h;
DOI:10.1016/j.tet.2007.06.089

Reference yield:

: 930304-05-5
1-benzyloxymethyl-2-methylsulfanylimidazole-4-carbaldehyde

: 951173-46-9
(Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butoxide / tetrahydrofuran / 0.08 h / 20 °C

1.2: 93 percent / tetrahydrofuran / 0.5 h / -78 °C

2.1: 99 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 15 h / 70 °C

With copper(l) iodide; potassium tert-butylate; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1.1: Stork-Zhao Wittig reaction / 2.1: Buchwald coupling;
DOI:10.1016/j.tet.2007.06.089

Reference yield:

: 1-benzyloxymethyl-2-methylsulfanyl-5-trimethylsilanyl-1H-imidazole-4-carbaldehyde

: 951173-46-9
(Z)-N-[2-(1-benzyloxymethyl-2-methylsulfanylimidazol-4-yl)vinyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3.79 g / potassium carbonate / methanol / 3 h / 20 °C

2.1: potassium tert-butoxide / tetrahydrofuran / 0.08 h / 20 °C

2.2: 93 percent / tetrahydrofuran / 0.5 h / -78 °C

3.1: 99 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 15 h / 70 °C

With copper(l) iodide; potassium tert-butylate; potassium carbonate; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; 2.1: Stork-Zhao Wittig reaction / 3.1: Buchwald coupling;
DOI:10.1016/j.tet.2007.06.089