ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate

Base Information

Chemical Name:ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate
CAS No.:1315280-95-5
Molecular Formula:C₂₄H₁₉BrN₂O₃S
Molecular Weight:495.396
Hs Code.:

Synonyms:ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate

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Technology Process of ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate

There total 3 articles about ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1315280-85-3
ethyl 4-(4-bromophenyl)-5-cyano-2-phenyl-6-thioxo-1,6-dihydropyridine-3-carboxylate

: 78-95-5
chloroacetone

: 1315280-95-5
ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1080/17415993.2011.576345

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 1315280-95-5
ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / ethanol / 6 h / Reflux

2: potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

With piperidine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; 1: Michael condensation;
DOI:10.1080/17415993.2011.576345

Reference yield:

: 68029-54-9,95639-00-2
3-(4-bromophenyl)-2-cyanoprop-2-enethioamide

: 1315280-95-5
ethyl 4-(4-bromophenyl)-5-cyano-6-[(2-oxopropyl)thio]-2-phenylnicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / ethanol / 6 h / Reflux

2: potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

With piperidine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; 1: Michael condensation;
DOI:10.1080/17415993.2011.576345