Technology Process of methyl (1R,3aS,5S,7aR)-5-cyclohexyl-3a-hydroxy-7a-methylperhydroindene-1-yl-(E)-acrylate
There total 12 articles about methyl (1R,3aS,5S,7aR)-5-cyclohexyl-3a-hydroxy-7a-methylperhydroindene-1-yl-(E)-acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
trimethyl phosphonoacetate;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
(1S,3aS,5S,7aR)-3a-hydroxy-5-cyclohexyl-7a-methylperhydroindene-1-carboxaldehyde;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
Further stages.;
DOI:10.1021/jm011001k
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 83 percent / oxalic acid / acetonitrile / 16 h
2.1: 77 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 2 h / Heating
3.1: BH3 / tetrahydrofuran / 1 h / 20 °C
3.2: 20 percent / NaBO3; aq. NaOH / 16 h / 20 °C
4.1: 68 percent / 1 N pTSA / acetonitrile; H2O / 16 h
5.1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C
6.1: 82 percent / Raney-Ni / ethanol; H2O / 3 h / Heating
7.1: 100 percent / H2 / 5percent Rh/Al203 / methanol / 4 h / 3268.22 Torr
8.1: 100 percent / IBX / dimethylsulfoxide / 1.5 h
9.1: NaH / tetrahydrofuran / 1 h / 0 °C
9.2: 100 percent / tetrahydrofuran / 2 h / 20 °C
With
borane; potassium tert-butylate; hydrogen; oxalic acid; nickel; sodium hydride; toluene-4-sulfonic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
5percent Rh/Al203;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; cyclohexane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;
2.1: Wittig reaction / 9.2: Horner-Emmons reaction;
DOI:10.1021/jm011001k
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C
2.1: 82 percent / Raney-Ni / ethanol; H2O / 3 h / Heating
3.1: 100 percent / H2 / 5percent Rh/Al203 / methanol / 4 h / 3268.22 Torr
4.1: 100 percent / IBX / dimethylsulfoxide / 1.5 h
5.1: NaH / tetrahydrofuran / 1 h / 0 °C
5.2: 100 percent / tetrahydrofuran / 2 h / 20 °C
With
hydrogen; nickel; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
5percent Rh/Al203;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; cyclohexane; water; dimethyl sulfoxide;
5.2: Horner-Emmons reaction;
DOI:10.1021/jm011001k
