(R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid

Base Information

Chemical Name:(R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid
CAS No.:941816-76-8
Molecular Formula:C₁₄H₁₅ClN₂O₅S
Molecular Weight:358.803
Hs Code.:

Synonyms:(R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid

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Chemical Property of (R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid

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Technology Process of (R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid

There total 5 articles about (R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372617-16-7
C₁₆H₂₂ClNO₆S

: 941816-76-8
(R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran

2: toluene-4-sulfonic acid / 1,4-dioxane / 60 °C

3: trifluoroacetic acid / dichloromethane

With benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.11.112

Reference yield:

: 1372617-48-5
C₂₀H₃₁ClN₂O₇S

: 941816-76-8
(R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 1,4-dioxane / 60 °C

2: trifluoroacetic acid / dichloromethane

With toluene-4-sulfonic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.11.112