(S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate
CAS No.:1610617-16-7
Molecular Formula:C₃₆H₃₆N₂O₃
Molecular Weight:544.693
Hs Code.:

Synonyms:(S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate

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Chemical Property of (S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate

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Technology Process of (S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate

There total 7 articles about (S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1610617-15-6
(S)-N-methoxy-N-methyl-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxamide

: 74965-31-4
N-(tert-butoxycarbonyl)-o-toluidine

: 1610617-16-7
(S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate

Guidance literature:: N-(tert-butoxycarbonyl)-o-toluidine; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -30 ℃; Inert atmosphere;

(S)-N-methoxy-N-methyl-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxamide; In tetrahydrofuran; cyclohexane; at -30 ℃; for 0.5h; Concentration; Inert atmosphere;
DOI:10.1002/ejoc.201301903

Reference yield:

: 55135-66-5
9-bromo-9-phenyl-9H-fluorene

: 1610617-16-7
(S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; lead(II) nitrate / acetonitrile / 24 h / Inert atmosphere

1.2: 0.5 h

2.1: isopropylmagnesium chloride / tetrahydrofuran / 5 h / 0 - 20 °C

3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -30 °C / Inert atmosphere

3.2: 0.5 h / -30 °C / Inert atmosphere

With potassium phosphate; lead(II) nitrate; sec.-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; cyclohexane; acetonitrile;
DOI:10.1002/ejoc.201301903

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1610617-16-7
(S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane / dichloromethane; acetonitrile / 1 h / Inert atmosphere; Reflux

1.2: 65 h / 20 °C / Inert atmosphere

2.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; dmap / ethyl acetate / 23 h / 20 °C

3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -30 °C / Inert atmosphere

3.2: 0.5 h / -30 °C / Inert atmosphere

With dmap; chloro-trimethyl-silane; sec.-butyllithium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane; ethyl acetate; acetonitrile;
DOI:10.1002/ejoc.201301903