74965-31-4

Basic information

• Product Name: O-TOLYL-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: O-TOLYL-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, (2-methylphenyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl o-tolylcarbamate;(2-Methylphenyl)carbaMic Acid 1,1-DiMethylethyl Ester;tert-Butyl N-(2-methylphenyl)carbamate
• CAS NO: 74965-31-4
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.26888
• Product Categories: N-BOC;Amines;Aromatics;Miscellaneous Reagents;amine|carboxylic ester
• Mol File: 74965-31-4.mol
• Article Data: 37

Chemical Properties

• Melting Point: 82-83 °C
• Boiling Point: 250.447°C at 760 mmHg
• Flash Point: 105.267°C
• Appearance: /
• Density: 1.064g/cm³
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.87±0.70(Predicted)
• CAS DataBase Reference: O-TOLYL-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: O-TOLYL-CARBAMIC ACID TERT-BUTYL ESTER(74965-31-4)
• EPA Substance Registry System: O-TOLYL-CARBAMIC ACID TERT-BUTYL ESTER(74965-31-4)

Safety Data

• Hazardous Substances Data: 74965-31-4(Hazardous Substances Data)

Usage

Chemical Properties

Solid

InChI:InChI=1/C12H17NO2/c1-9-7-5-6-8-10(9)13-11(14)15-12(2,3)4/h5-8H,1-4H3,(H,13,14)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 95-53-4 o-toluidine 
• 4248-19-5 tert-butyl carbazate 
• 95-49-8 2-methylchlorobenzene 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 62-53-3 aniline 
• 88-72-2 1-methyl-2-nitrobenzene 
• 396094-75-0 2-[2'-(N,N-di-tert-butoxycarbonylamino)phenyl]-1,3-dithiane 
• 396094-78-3 2-[2'-(N-Boc-amino)phenyl]-1,3-dithiane 
• 3422-01-3 tert-butyl phenylcarbamate 
• 74-88-4 methyl iodide 
• 95-46-5 2-methylphenyl bromide 
• 74965-30-3 C₁₁H₁₃LiNO₂^(1-)*Li⁽¹⁺⁾ 

Downstream Products

• 129822-52-2 [2-(2-Oxo-2-phenyl-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 209967-17-9 4-(2-aminophenyl)-1-butanol 
• 909297-57-0 [2-(2-hydroxy-3,3-dimethyl-2-phenyl-butyl)-phenyl]-carbamic acid tert-butyl ester 
• 37072-63-2 N-(2-methylphenyl)oxazolidin-2-one 
• 1255763-32-6 C₂₄H₂₆NO₂P 
• 1610617-16-7 (S)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate 
• 1610617-17-8 (S)-ethyl 2-{2-[1-(9-Phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]-1Hindol-3-yl}acetate 
• 1610617-18-9 (R)-ethyl 2-{2-[1-(9-Phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]-1Hindol-3-yl}acetate 
• 1610617-25-8 (R)-tert-butyl (2-{2-oxo-2-[1-(9-phenyl-9H-fluoren-9-yl)pyrrolidin-2-yl]ethyl}phenyl)carbamate 

Relevant articles and documents

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Copper(ii)-hydroxide facilitated C-C bond formation: The carboxamido pyridine system: Versus the methylimino pyridine system

A copper(ii)-hydroxide-induced carbon-carbon bond formation reaction is explored with the synthesis of an asymmetric carboxamido-methylimino pyridine Cu(i) complex of [CuI(py(N-CO)(NC-C)ph2Me2)2]- (12). Two imine-methyl groups are coupled to form a bridge