8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline

Base Information

Chemical Name:8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline
CAS No.:73931-28-9
Molecular Formula:C₂₇H₂₃F₃N₂*ClH
Molecular Weight:468.949
Hs Code.:

Synonyms:8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline

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Chemical Property of 8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline

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Technology Process of 8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline

There total 6 articles about 8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 70801-02-4,62655-22-5
8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-hydroxybutyl>-2,3,4,5-tetrahydro-1H-pyridio<4,3-b>indole

: 73931-28-9
8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline

Guidance literature:: With hydrogenchloride; In ethanol; for 4h; Heating;
DOI:10.1021/jm00180a011

Reference yield:

: 58038-66-7
2-carbethoxy-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido<4,3-b>indole

: 73931-28-9
8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / cuprous bromide, sodium carbonate / various solvent(s) / 8 h / 200 °C

2: 41 percent / KOH, water / ethanol / 23 h / Heating

3: NaCO₃, KI / dimethylformamide / 4 h / 65 °C

4: NaBH₄ / ethanol; tetrahydrofuran / 0.5 h

5: 37 percent / 6N HCl / ethanol / 4 h / Heating

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; water; sodium carbonate; potassium iodide; copper(I) bromide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a011

Reference yield:

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 73931-28-9
8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)but-3-enyl>-1,2,3,4-tetrahydro-γ-carboline

Guidance literature:: Multi-step reaction with 3 steps

1: NaCO₃, KI / dimethylformamide / 4 h / 65 °C

2: NaBH₄ / ethanol; tetrahydrofuran / 0.5 h

3: 37 percent / 6N HCl / ethanol / 4 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a011