4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester

Base Information

Chemical Name:4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester
CAS No.:1443684-36-3
Molecular Formula:C₂₂H₁₆F₂N₂O₂
Molecular Weight:378.378
Hs Code.:

Synonyms:4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester

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Chemical Property of 4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester

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Technology Process of 4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester

There total 8 articles about 4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.52%

: 1443684-77-2
2-(2,6-difluoro-phenyl)-5-(4-methoxycarbonyl-2-methyl-phenyl)-pyrrolo[2,3-b]pyridine-1-carboxylic acid ethyl ester

: 1443684-36-3
4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 20 ℃; for 2h;

Reference yield:

: 1443684-75-0
5-bromo-2-(2,6-difluoro-phenyl)-pyrrolo[2,3-b]pyridine-1-carboxylic acid ethyl ester

: 1443684-36-3
4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C

2: sodium hydroxide / methanol / 2 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; 1: |Suzuki Coupling;

Reference yield:

: 271-63-6
7-Azaindole

: 1443684-36-3
4-[2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine; tert-butyl alcohol / water / 24 h / 20 °C

2.1: zinc; acetic acid / water / 3 h / 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

3.2: 1.5 h / 0 °C

4.1: ammonium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 1 h / 100 °C

7.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C

8.1: sodium hydroxide / methanol / 2 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; ammonium carbonate; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; tert-butyl alcohol; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6.1: |Suzuki Coupling / 7.1: |Suzuki Coupling;